2010
Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis
Prasse A, Zissel G, Lützen N, Schupp J, Schmiedlin R, Gonzalez-Rey E, Rensing-Ehl A, Bacher G, Cavalli V, Bevec D, Delgado M, Müller-Quernheim J. Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis. American Journal Of Respiratory And Critical Care Medicine 2010, 182: 540-548. PMID: 20442436, DOI: 10.1164/rccm.200909-1451oc.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideRegulatory T cellsT cellsImmunoregulatory effectsImmunoregulatory roleLung disordersVIP treatmentCapacity of VIPChronic inflammatory lung disordersPeripheral regulatory T cellsTumor necrosis factor-alpha productionClinical phase II studyNecrosis factor-alpha productionConventional effector T cellsEpitheloid cell granulomasFatal organ dysfunctionPhase II studyEffector T cellsExaggerated immune responseChronic lung inflammationInflammatory lung disordersBronchoalveolar lavage fluidNew therapeutic principleImportant immunoregulatory roleActive disease
2005
Enhanced TLR4 reactivity following injury is mediated by increased p38 activation
Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. Journal Of Leukocyte Biology 2005, 78: 565-573. PMID: 15857937, DOI: 10.1189/jlb.1204698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBurnsCells, CulturedEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationImidazolesLipopolysaccharidesMacrophagesMaleMembrane GlycoproteinsMiceMyoD ProteinProtein KinasesPyridinesReceptors, Cell SurfaceSignal TransductionSpleenToll-Like Receptor 4Toll-Like ReceptorsConceptsMitogen-activated protein kinaseExtracellular signal-regulated kinaseStress-activated protein kinaseP38 activationJun N-terminal kinase (JNK) mitogen-activated protein kinaseProtein kinaseKinase mitogen-activated protein kinaseSAPK/JNK activationProtein-2 proteinTLR4 reactivitySham miceSpecific p38 inhibitorSignal-regulated kinaseInterleukin-1 receptor-associated kinaseDay 1Receptor-associated kinaseMyeloid differentiation primary response protein 88Tumor necrosis factor-alpha productionToll-like receptor 4Necrosis factor-alpha productionCell surface expressionTLR4 mRNA expressionInjury-induced increaseProinflammatory cytokine productionInjury-induced changes
2000
Induction of tumor necrosis factor α production by adhered human monocytes: A key role for Fcγ receptor type IIIA in rheumatoid arthritis
Abrahams V, Cambridge G, Lydyard P, Edwards J. Induction of tumor necrosis factor α production by adhered human monocytes: A key role for Fcγ receptor type IIIA in rheumatoid arthritis. Arthritis & Rheumatism 2000, 43: 608-616. PMID: 10728755, DOI: 10.1002/1529-0131(200003)43:3<608::aid-anr18>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsIL-1alpha productionPresence of TNFalphaRheumatoid arthritisImmune complexesSmall immune complexesHuman monocytesTNFalpha productionFcgammaRIIIa receptorTumor necrosis factor-alpha productionTumor Necrosis Factor-α ProductionNecrosis factor-alpha productionLevels of TNFalphaIgG Fc receptorsEnzyme-linked immunosorbentMonocyte-derived macrophagesMurine monoclonal antibodiesAlpha productionΑ productionInterleukin-1alphaFc receptorsType IIIATNFalphaArthritisHuman macrophagesMonocytes
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