2018
Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis
Nguyen J, Jiao J, Smoot K, Watt G, Zhao C, Song X, Stevenson H, McCormick J, Fisher-Hoch S, Zhang J, Futreal P, Beretta L. Toll-like receptor 4: a target for chemoprevention of hepatocellular carcinoma in obesity and steatohepatitis. Oncotarget 2018, 9: 29495-29507. PMID: 30034633, PMCID: PMC6047684, DOI: 10.18632/oncotarget.25685.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseTLR4 mRNA expressionHepatocellular carcinomaMRNA expressionIL-6HCC patientsHCC developmentHCC tumorsIL-10 mRNA expressionToll-like receptor 4Fatty liver diseaseWhole-exome sequencingIngenuity Pathway AnalysisDistant liverIL-10Liver diseaseTLR4 inhibitorProinflammatory responseReceptor 4TLR4 activationHCC chemopreventionChemopreventionKey mediatorTumorsMice
2005
Enhanced TLR4 reactivity following injury is mediated by increased p38 activation
Maung AA, Fujimi S, Miller ML, MacConmara MP, Mannick JA, Lederer JA. Enhanced TLR4 reactivity following injury is mediated by increased p38 activation. Journal Of Leukocyte Biology 2005, 78: 565-573. PMID: 15857937, DOI: 10.1189/jlb.1204698.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBurnsCells, CulturedEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationImidazolesLipopolysaccharidesMacrophagesMaleMembrane GlycoproteinsMiceMyoD ProteinProtein KinasesPyridinesReceptors, Cell SurfaceSignal TransductionSpleenToll-Like Receptor 4Toll-Like ReceptorsConceptsMitogen-activated protein kinaseExtracellular signal-regulated kinaseStress-activated protein kinaseP38 activationJun N-terminal kinase (JNK) mitogen-activated protein kinaseProtein kinaseKinase mitogen-activated protein kinaseSAPK/JNK activationProtein-2 proteinTLR4 reactivitySham miceSpecific p38 inhibitorSignal-regulated kinaseInterleukin-1 receptor-associated kinaseDay 1Receptor-associated kinaseMyeloid differentiation primary response protein 88Tumor necrosis factor-alpha productionToll-like receptor 4Necrosis factor-alpha productionCell surface expressionTLR4 mRNA expressionInjury-induced increaseProinflammatory cytokine productionInjury-induced changes
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