The Requirement for Mechanical Coupling Between Head and S2 Domains in Smooth Muscle Myosin ATPase Regulation and its Implications for Dimeric Motor Function
Tama F, Feig M, Liu J, Brooks C, Taylor K. The Requirement for Mechanical Coupling Between Head and S2 Domains in Smooth Muscle Myosin ATPase Regulation and its Implications for Dimeric Motor Function. Journal Of Molecular Biology 2005, 345: 837-854. PMID: 15588830, DOI: 10.1016/j.jmb.2004.10.084.Peer-Reviewed Original ResearchConceptsMyosin headsAlpha-helicesATP-dependent molecular motorSmooth muscle myosin IIMyosin II regulationCoiled-coil domainMuscle myosin IIInhibited stateMolecular motorsMyosin IIATPase regulationDimerization domainElastic network normal mode analysisAlpha-helixDomain movementsHomology modelingFunction of molecular motorsMyosinBiochemical dataConformational transitionRegulationNormal mode analysisExperimental structural dataStructural dataHeptad
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