2017
Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography
Gamm UA, Huang BK, Mis EK, Khokha MK, Choma MA. Visualization and quantification of injury to the ciliated epithelium using quantitative flow imaging and speckle variance optical coherence tomography. Scientific Reports 2017, 7: 15115. PMID: 29118359, PMCID: PMC5678121, DOI: 10.1038/s41598-017-14670-9.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyCiliated epitheliumCoherence tomographyType of injuryExtent of injuryQuantification of injuryVariance optical coherence tomographyRespiratory infectionsDiffuse injuryFocal injuryImportant defense mechanismMouse tracheaInjuryMucociliary flowEpitheliumRegeneration of ciliaTomographyMultiple factorsDefense mechanismsQuantitative flowLungInfectionTracheaDisease
2015
Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography
Gamm UA, Huang BK, Syed M, Zhang X, Bhandari V, Choma MA. Quantifying hyperoxia-mediated damage to mammalian respiratory cilia-driven fluid flow using particle tracking velocimetry optical coherence tomography. Journal Of Biomedical Optics 2015, 20: 080505-080505. PMID: 26308164, PMCID: PMC4874052, DOI: 10.1117/1.jbo.20.8.080505.Peer-Reviewed Original ResearchConceptsOptical coherence tomographyMouse tracheaCoherence tomographyDrug-mediated modulationIntensive care unitRisk-benefit profileRespiratory failureCare unitOxygen supplementationRespiratory mucosaRespiratory epitheliumIndispensable treatmentImpaired capacityClinical useHyperoxiaTracheaFlow quantificationTomographyTreatmentDamagePatientsMucosaSupplementationEpithelium
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