2018
Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans
Cheng Z, Zhou H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans. Biological Psychiatry 2018, 84: 762-770. PMID: 29478698, PMCID: PMC6041180, DOI: 10.1016/j.biopsych.2017.12.016.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesHomologous mouse geneMouse geneAxon guidance proteinRegulatory variantsCoexpression analysisOpioid dependenceTranscript variantsGenetic studiesChromosome 15Guidance proteinsRNA expressionNominal significanceMessenger RNA expressionGenesRepulsive guidance molecule AHigh expressionRGMaRisk allelesChronic morphine injectionDSM-IV diagnosisExpressionNew leadsMorphine injection
1994
A context-specific detrimental effect of UCS preexposure on place conditioning with morphine
McKee S, Hinson R, Baxter B. A context-specific detrimental effect of UCS preexposure on place conditioning with morphine. Learning & Behavior 1994, 22: 282-290. DOI: 10.3758/bf03209836.Peer-Reviewed Original Research
1993
The effect of the CS-UCS interval and extinction on place conditioning and analgesic tolerance with morphine
Hinson R, McKee S, Lovenjak T, Wall A. The effect of the CS-UCS interval and extinction on place conditioning and analgesic tolerance with morphine. Journal Of Psychopharmacology 1993, 7: 164-172. PMID: 22290663, DOI: 10.1177/026988119300700204.Peer-Reviewed Original ResearchPlace preferencePlace conditioning trainingAnalgesic effectAnalgesic toleranceMorphine injectionPlace conditioningHot plate testOnly salineSaline injectionConditioning trainingMorphinePlace conditioning apparatusInterval studyHome cageExtinction trialsSeparate groupsInjectionCS-UCS intervalEnd compartments
1992
Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine
Sofuoglu M, Portoghese P, Takemori A. Maintenance of acute morphine tolerance in mice by selective blockage of κ opioid receptors with norbinaltorphimine. European Journal Of Pharmacology 1992, 210: 159-162. PMID: 1318206, DOI: 10.1016/0014-2999(92)90666-r.Peer-Reviewed Original ResearchConceptsMorphine injectionSelective kappa opioid antagonistED50 valuesKappa-opioid antagonistAcute morphine toleranceTail-flick assayDevelopment of toleranceKappa-opioid sitesAntinociceptive ED50 valueNon-pretreated controlsSupraspinal sitesOpioid toleranceMorphine administrationControl miceMorphine sulfateMorphine toleranceOpioid agonistsOpioid antagonistSpinal sitesSingle doseOpioid receptorsOpioid sitesMorphineMiceSelective blockage
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply