2025
scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links
Wang G, Zhao J, Lin Y, Liu T, Zhao Y, Zhao H. scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links. Nature Communications 2025, 16: 4994. PMID: 40442129, PMCID: PMC12122792, DOI: 10.1038/s41467-025-60333-z.Peer-Reviewed Original ResearchConceptsDeep learning frameworkSingle-cell multi-omics researchSingle-cell multi-omics dataLearning frameworkMulti-omics dataGenerative adversarial networkSingle-cell technologiesData alignmentSingle-cell resolutionMulti-omics researchDownstream analysisCellular statesOmics datasetsAdversarial networkNeural networkProteomic profilingCorrelated featuresBiological informationOmics perspectiveDiverse datasetsFeature topologyDisease mechanismsCell embeddingData resourcesRelationship inference
2023
Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study
Abdi M, Aliyev E, Trost B, Kohailan M, Aamer W, Syed N, Shaath R, Gandhi G, Engchuan W, Howe J, Thiruvahindrapuram B, Geng M, Whitney J, Syed A, Lakshmi J, Hussein S, Albashir N, Hussein A, Poggiolini I, Elhag S, Palaniswamy S, Kambouris M, de Fatima Janjua M, Tahir M, Nazeer A, Shahwar D, Azeem M, Mokrab Y, Aati N, Akil A, Scherer S, Kamal M, Fakhro K. Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study. Genome Medicine 2023, 15: 81. PMID: 37805537, PMCID: PMC10560429, DOI: 10.1186/s13073-023-01228-w.Peer-Reviewed Original ResearchConceptsTandem repeat expansionsSingle nucleotide variantsGenetic architectureNovel ASD candidate genesWhole-genome sequencing dataMitochondrial DNA variantsASD candidate genesMulti-omics researchGenomic architectureRecessive variationMtDNA variantsCandidate genesDNA variantsSequencing dataRepeat expansionNumber variantsSNVs/indelsDe novoNon-consanguineous familyGenesGenetics guidelinesUnique resourcePathogenic variantsFamilyMedical Genetics guidelines
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply