2017
Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation
Kaiser R, Treadway M, Wooten D, Kumar P, Goer F, Murray L, Beltzer M, Pechtel P, Whitton A, Cohen A, Alpert N, Fakhri G, Normandin M, Pizzagalli D. Frontostriatal and Dopamine Markers of Individual Differences in Reinforcement Learning: A Multi-modal Investigation. Cerebral Cortex 2017, 28: 4281-4290. PMID: 29121332, PMCID: PMC6454484, DOI: 10.1093/cercor/bhx281.Peer-Reviewed Original ResearchConceptsDA transporterRL behaviourVentral striatumDA clearanceFunctional connectivityBinding potentialLevel of neurocognitive functioningIncreased intrinsic functional connectivityMulti-modal neuroimaging studiesResting-state functional connectivityPhasic DA activityStriatal DA transporterIntrinsic functional connectivityReinforcement learning behaviorMulti-modal investigationsFrontostriatal circuitsFrontostriatal connectivityFrontostriatal regionsOrbitofrontal cortexDA activityNeuroimaging studiesOrbitofrontal regionsDopamine markersNeurocognitive functionDopamine
2016
Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial
Saunders K, Cipriani A, Rendell J, Attenburrow M, Nelissen N, Bilderbeck A, Vasudevan S, Churchill G, Goodwin G, Nobre A, Harmer C, Harrison P, Geddes J. Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial. Trials 2016, 17: 116. PMID: 26936776, PMCID: PMC4776410, DOI: 10.1186/s13063-016-1230-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAntimanic AgentsBiomarkersBipolar DisorderBrainClinical ProtocolsCognitionDouble-Blind MethodEnglandFemaleGene Expression RegulationHumansLithium CarbonateMagnetic Resonance ImagingMagnetoencephalographyMaleNeuropsychological TestsProspective StudiesPsychiatric Status Rating ScalesResearch DesignTime FactorsTreatment OutcomeYoung AdultConceptsBipolar disorderLithium trialExperimental medicine modelEffects of lithium carbonateMulti-modal investigationsMood stabilisersMood instabilityPlacebo-controlled studyCognitive testsLithium treatmentLithium carbonateDouble-blindDisordersMoodCircadian effectsMedicine modelBiochemical effectsRandomised controlled trialsTherapeutic responseParticipantsEarly effectsSide effectsClinical useFMRIEffective drugs
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