2024
Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions
Gao Y, Shonai D, Trn M, Zhao J, Soderblom E, Garcia-Moreno S, Gersbach C, Wetsel W, Dawson G, Velmeshev D, Jiang Y, Sloofman L, Buxbaum J, Soderling S. Proximity analysis of native proteomes reveals phenotypic modifiers in a mouse model of autism and related neurodevelopmental conditions. Nature Communications 2024, 15: 6801. PMID: 39122707, PMCID: PMC11316102, DOI: 10.1038/s41467-024-51037-x.Peer-Reviewed Original ResearchConceptsSpatial proteomicsRisk genesHigh-confidence risk genesRegulation of expressionAutism risk genesGenetic interactionsProximity proteomicsHuman genesEndogenous proteomesProtein complexesCellular functionsNative proteomeProteomicsPhenotypic modifiersRisk allelesRelevant to autismGenesFunctional interactionsGenetic riskProteinMouse brainMouse model of autismCellular driversProximity interactionsMouse model
2018
Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability
Zamarbide M, Mossa A, Muñoz-Llancao P, Wilkinson M, Pond H, Oaks A, Manzini M. Male-Specific cAMP Signaling in the Hippocampus Controls Spatial Memory Deficits in a Mouse Model of Autism and Intellectual Disability. Biological Psychiatry 2018, 85: 760-768. PMID: 30732858, PMCID: PMC6474812, DOI: 10.1016/j.biopsych.2018.12.013.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive deficitsIntellectual disabilitySpectrum disorderNeurodevelopmental disordersMouse model of autismFemale miceRegulates cyclic adenosine monophosphateSpatial memory deficitsModel of autismPrevalence of neurodevelopmental disordersMale micePDE4D activityMale-specific mannerMemory deficitsSpatial memoryCyclic adenosine monophosphateIntracellular signalingBehavioral studiesMolecular deficitsAutismBehavioral differencesHippocampusCC2D1ADeficits
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