2021
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Maxwell Scalf S, Eastman AE, Chen JJ, Zhu LJ, Heuberger JAAC, Guo S, Koury MJ, Nordsborg NB, Socolovsky M. EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications 2021, 12: 7334. PMID: 34921133, PMCID: PMC8683474, DOI: 10.1038/s41467-021-27562-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, CDbcl-X ProteinCD4 AntigensCell CycleCell DifferentiationCell NucleusCell SizeCell SurvivalCyclin-Dependent Kinase Inhibitor p27Embryo, MammalianErythroblastsErythrocytesErythropoiesisErythropoietinFemaleFetusHealthy VolunteersHumansIronLiverMaleMice, Inbred C57BLModels, BiologicalProtein Serine-Threonine KinasesReceptors, ErythropoietinReceptors, TransferrinReticulocytesSignal TransductionConceptsCell size regulationCell sizeSequential cell divisionsEpoR functionErythroblast survivalMouse erythroblastsCell divisionSize regulationHuman erythropoiesisErythropoietin receptorCell cycleEpoRHypoxic stressRed cell sizeHigh erythropoietinLarger red cellsWild-type miceCyclingErythroblastsRegulationHigher EPO levelsMiceRed cellsSurvivalErythropoiesis
2014
Mmu-Mir-181a Regulates Terminal Erythroid Nuclear Maturation By Regulating Levels of Xpo7
Figueroa A, Martinez-Morilla S, Venkatesan S, Hattangadi S. Mmu-Mir-181a Regulates Terminal Erythroid Nuclear Maturation By Regulating Levels of Xpo7. Blood 2014, 124: 2669. DOI: 10.1182/blood.v124.21.2669.2669.Peer-Reviewed Original ResearchErythroid developmentGenomic structureExportin-7Chromatin condensationMiR-181aRed blood cell developmentTermination of transcriptionBlood cell developmentHematopoietic lineage differentiationNormal erythroid developmentTerminal erythroid differentiationSuch important processesCell cycle arrestErythroid nucleiMiR-181a binding siteNuclear maturationMouse erythroblastsHematopoietic stem cellsCore histonesNuclear proteinsStart siteLineage differentiationMegakaryocyte developmentXPO7Erythroid differentiation
2013
Histones To The Cytosol: Role Of Nuclear Protein Export In Erythroid Nuclear Condensation
Figueroa A, Venkatesan S, Hattangadi S. Histones To The Cytosol: Role Of Nuclear Protein Export In Erythroid Nuclear Condensation. Blood 2013, 122: 310. DOI: 10.1182/blood.v122.21.310.310.Peer-Reviewed Original ResearchNuclear protein exportErythroid-specific promoterProtein exportNuclear condensationChromatin condensationLate erythroblastsReplacement of histonesFetal liver erythroblastsMouse fetal liverNuclear exportinCargo proteinsMouse erythroblastsHistone H2AChromatin immunoprecipitationExportin-7Nuclear exportRACE-PCRNuclear proteinsLower vertebratesKnockdown cellsXPO7Erythroid differentiationCell biology conceptsProteomic examinationErythroblast nuclei
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