How many patients do you need? Investigating trial designs for anti‐seizure treatment in acute brain injury patients
Parikh H, Sun H, Amerineni R, Rosenthal E, Volfovsky A, Rudin C, Westover M, Zafar S. How many patients do you need? Investigating trial designs for anti‐seizure treatment in acute brain injury patients. Annals Of Clinical And Translational Neurology 2024, 11: 1681-1690. PMID: 38867375, PMCID: PMC11251465, DOI: 10.1002/acn3.52059.Peer-Reviewed Original ResearchConceptsRandomized Controlled TrialsAnti-seizure treatmentAcute brain injuryEpileptiform activityBrain injuryTreatment armsModel treatment responsePlacebo-controlled trialAcute brain injury patientsSingle-center cohortDrug efficacy dataBrain injury patientsCohort of adultsDischarge modified Rankin ScaleFeasibility of randomized controlled trialsSample sizePlacebo armTreatment responseDrug doseEA trajectoriesEfficacy dataWorsen outcomesRankin ScaleDrug efficacyPlacebo
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