Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Li D, Mastaglia F, Fletcher S, Wilton S. Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era. Medicinal Research Reviews 2020, 40: 2650-2681. PMID: 32767426, PMCID: PMC7589267, DOI: 10.1002/med.21718.Peer-Reviewed Original ResearchConceptsNucleic acid therapeuticsPathogenesis of PDMolecular pathogenesisTargeted gene sequencingDownstream molecular eventsStratify PD patientsSmall interfering RNATargeting critical elementsParkinson's diseaseShort hairpin RNANucleic acid compoundsGene sequencesBlood-brain barrierMolecular pathogenesis of PDPrecision medicine eraDisease-modifying therapiesReduced life expectancyModify disease progressionPD clinical trialsGenetic pathogenesisNucleic acid oligomersHairpin RNAMolecular eventsMolecular therapiesClinical trials
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