Isoallopregnanolone reduces tic‐like behaviours in the D1CT‐7 mouse model of Tourette syndrome
Cadeddu R, Bäckström T, Floris G, Nordkild P, Segerdahl M, Bortolato M. Isoallopregnanolone reduces tic‐like behaviours in the D1CT‐7 mouse model of Tourette syndrome. Journal Of Neuroendocrinology 2019, 32: e12754. PMID: 31175669, DOI: 10.1111/jne.12754.Peer-Reviewed Original ResearchConceptsD1CT-7 miceTic-like behavioursTourette syndromePositive allosteric modulators of GABA<sub>A</sub> receptorsExposure to acute stressAllosteric modulators of GABA<sub>A</sub> receptorsSensorimotor gating deficitsModulators of GABA<sub>A</sub> receptorsPositive allosteric modulatorsEffects of stressModel of TSAnimal model of TSPrepulse inhibitionGating deficitsWell-characterised animal modelsPersistent ticsNeuropsychiatric disordersNeurosteroid allopregnanoloneAcute stressAllopregnanoloneBrain synthesisSecondary to stressOptimal safety profilePrepulseIsoallopregnanolone
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply