2024
Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome
Cadeddu R, Braccagni G, Branca C, van Luik E, Pittenger C, Thomsen M, Bortolato M. Activation of M4 muscarinic receptors in the striatum reduces tic‐like behaviours in two distinct murine models of Tourette syndrome. British Journal Of Pharmacology 2024, 181: 3064-3081. PMID: 38689378, DOI: 10.1111/bph.16392.Peer-Reviewed Original ResearchPositive allosteric modulatorsD1CT-7 miceTourette syndromeMouse model of TSStriatal cholinergic interneuronsTic-like behavioursC-Fos levelsModel of TSActivate c-fosM4 muscarinic receptorsMuscarinic receptorsStriatal acetylcholineMouse modelStriatal expressionTic-likeStriatal levelsCholinergic interneuronsVU0467154Current pharmacotherapyXanomelineReceptor agonistsAllosteric modulatorsC-fosReceptor antagonistStriatum
2019
Isoallopregnanolone reduces tic‐like behaviours in the D1CT‐7 mouse model of Tourette syndrome
Cadeddu R, Bäckström T, Floris G, Nordkild P, Segerdahl M, Bortolato M. Isoallopregnanolone reduces tic‐like behaviours in the D1CT‐7 mouse model of Tourette syndrome. Journal Of Neuroendocrinology 2019, 32: e12754. PMID: 31175669, DOI: 10.1111/jne.12754.Peer-Reviewed Original ResearchConceptsD1CT-7 miceTic-like behavioursTourette syndromePositive allosteric modulators of GABA<sub>A</sub> receptorsExposure to acute stressAllosteric modulators of GABA<sub>A</sub> receptorsSensorimotor gating deficitsModulators of GABA<sub>A</sub> receptorsPositive allosteric modulatorsEffects of stressModel of TSAnimal model of TSPrepulse inhibitionGating deficitsWell-characterised animal modelsPersistent ticsNeuropsychiatric disordersNeurosteroid allopregnanoloneAcute stressAllopregnanoloneBrain synthesisSecondary to stressOptimal safety profilePrepulseIsoallopregnanolone
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