Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
Mostafavi S, Balafkan N, Pettersen I, Nido G, Siller R, Tzoulis C, Sullivan G, Bindoff L. Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model. Frontiers In Cell And Developmental Biology 2021, 9: 744777. PMID: 34722525, PMCID: PMC8553110, DOI: 10.3389/fcell.2021.744777.Peer-Reviewed Original ResearchGlycolysis to oxidative phosphorylationMitochondrial remodelingOxidative phosphorylationMesoderm differentiationRemodeling of mitochondriaMitochondrial contentGerm layer specificationStem cell fateIncreased mitochondrial activityATP-linked respirationIncreased OXPHOS activityCell fateMitochondria remodelingOXPHOS activityRegulate self-renewalMitochondrial activityMultipotent stateMitochondrial adaptationsEctoderm commitmentMitochondriaStem cell modelNeuronal differentiationMesodermal derivativesEndodermal lineagesGlycolysis
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