2025
Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan
Jeong D, Lee D, Kim S, Jeoung S, Zhao D, Knight J, Lam T, Jin J, Lee H, Hochstrasser M, Ryu H. Auto-sumoylation of the yeast Ubc9 E2 SUMO-conjugating enzyme extends cellular lifespan. Nature Communications 2025, 16: 3735. PMID: 40254622, PMCID: PMC12009981, DOI: 10.1038/s41467-025-58925-w.Peer-Reviewed Original ResearchConceptsE2 SUMO-conjugating enzymeSUMO-conjugating enzymeSUMO-specific proteasesPost-translational levelIn vitro evolutionSevere cellular stressCalorie restrictionRegulation of multiple targetsGene expression profilesIncreased mitochondrial activityCellular lifespanLifespan extensionReplicative lifespanCellular stressMitochondrial activityYeastCR-mediated lifespan extensionEnhanced growth rateEnzyme resultsDiverse processesExpression profilesLifespan effectsReplication abilityEnergy metabolismAged cells
2021
Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model
Mostafavi S, Balafkan N, Pettersen I, Nido G, Siller R, Tzoulis C, Sullivan G, Bindoff L. Distinct Mitochondrial Remodeling During Mesoderm Differentiation in a Human-Based Stem Cell Model. Frontiers In Cell And Developmental Biology 2021, 9: 744777. PMID: 34722525, PMCID: PMC8553110, DOI: 10.3389/fcell.2021.744777.Peer-Reviewed Original ResearchGlycolysis to oxidative phosphorylationMitochondrial remodelingOxidative phosphorylationMesoderm differentiationRemodeling of mitochondriaMitochondrial contentGerm layer specificationStem cell fateIncreased mitochondrial activityATP-linked respirationIncreased OXPHOS activityCell fateMitochondria remodelingOXPHOS activityRegulate self-renewalMitochondrial activityMultipotent stateMitochondrial adaptationsEctoderm commitmentMitochondriaStem cell modelNeuronal differentiationMesodermal derivativesEndodermal lineagesGlycolysis
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