1986
Radiosensitization, pharmacokinetics, and toxicity of a 2-nitroimidazole nucleoside (RA-263).
Agrawal K, Rupp W, Rockwell S. Radiosensitization, pharmacokinetics, and toxicity of a 2-nitroimidazole nucleoside (RA-263). Radiation Research 1986, 105: 227-39. PMID: 3754053, DOI: 10.2307/3576548.Peer-Reviewed Original ResearchConceptsEMT6 mammary tumorsRapid alpha phaseSlower beta phaseMammary tumor cellsEffect of radiosensitizationRadiation survival curvesTumor concentrationsMammary tumorsPotent radiosensitizerPharmacokinetic dataHypoxic Chinese hamster cellsSurvival curvesTumor cellsHypoxic cellsMisonidazoleHypoxic cell toxicityRadiosensitization experimentsSignificant decreaseHypoxic conditionsRadiosensitization activityExtrapolation numberEquimolar basisPharmacokineticsRadiosensitizationLD50 test
1984
Enhancement of artificial lung metastases by misonidazole
Rockwell S, Nierenburg M, Irvin C. Enhancement of artificial lung metastases by misonidazole. International Journal Of Radiation Oncology • Biology • Physics 1984, 10: 1395-1398. PMID: 6469763, DOI: 10.1016/0360-3016(84)90356-0.Peer-Reviewed Original ResearchConceptsArtificial lung metastasesLung metastasesHypoxic cell radiosensitizer misonidazoleEMT6 mouse mammary carcinoma cellsLung tumor formationMouse mammary carcinoma cellsEffect of treatmentMammary carcinoma cellsLung tumorsIntravenous injectionPhysiologic effectsLarge dosesRadiosensitizer misonidazoleSmall dosesSingle treatmentCarcinoma cellsMisonidazoleTumor formationMetastasisTreatmentDosesTumors
1982
Dose-response curves for predicting misonidazole-induced peripheral neuropathy.
Schwade J, Makuch R, Strong J, Glatstein E. Dose-response curves for predicting misonidazole-induced peripheral neuropathy. Journal Of The National Cancer Institute 1982, 66: 1743-50. PMID: 6288238.Peer-Reviewed Original ResearchConceptsPeripheral neuropathyLinear logistic regression analysisTotal cumulative doseLogistic regression analysisLogistic regression modelsDose-response curveCumulative AUCCumulative dosePlasma eliminationPlasma concentrationsNeuropathyLinear logistic regression modelPharmacokinetic parametersPharmacokinetic curveCancer treatmentToxic agentsRegression analysisAUCRegression modelsPatientsPharmacokineticsDoseMisonidazole
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