Intracellular C3 prevents hepatic steatosis by promoting autophagy and very‐low‐density lipoprotein secretion
Li Y, Sha Y, Wang H, He L, Li L, Wen S, Sheng L, Hu W, Zhou H. Intracellular C3 prevents hepatic steatosis by promoting autophagy and very‐low‐density lipoprotein secretion. The FASEB Journal 2021, 35: e22037. PMID: 34762761, DOI: 10.1096/fj.202100856r.Peer-Reviewed Original ResearchConceptsVery-low-density lipoprotein secretionVery-low-density lipoproteinProtein disulfide isomeraseExpression of protein disulfide isomeraseMicrosomal TG transfer proteinPathogen recognitionHepatic lipid accumulationDisulfide isomeraseEndoplasmic reticulumIntracellular functionsAutophagy-relatedExtracellular milieuDisrupt interactionsVLDL secretionTransfer proteinLipoprotein secretionLipid accumulationIntracellular C3C3<sup>-/-</sup> miceComplement component C3C3 knockoutHepatic steatosisConvergence pointWild type miceKnockout
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