2023
P-001 ClpX is required in maintaining mitochondrial functions during meiosis and spermatogenesis
Guo C, Xiao Y, Gu J, Hua R, Hai Z, Su J, Wang T. P-001 ClpX is required in maintaining mitochondrial functions during meiosis and spermatogenesis. Human Reproduction 2023, 38 DOI: 10.1093/humrep/dead093.371.Peer-Reviewed Original ResearchGerm cellsMitochondrial functionEnergy of ATP bindingQuality control proteasesHigh-throughput sequencing techniquesApoptotic germ cellsMale germ cellsMeiotic germ cellsCross-over eventsRapamycin treatment in vivoGerm cells of male miceIsolated spermatocytesAAA+ proteasesControl proteasesDegradation tagSpermatogonia differentiationRegulate spermatogenesisCre-loxP systemKnockout mouse lineChromosome synapsisMisfolded proteinsProtein substratesMitochondrial matrixClpXDecreased testicular size
2008
Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis
Kim S, Kim J, Han J, Yoon Y. Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis. International Journal Of Toxicology 2008, 27: 175-182. PMID: 18404541, DOI: 10.1080/10915810801977906.Peer-Reviewed Original ResearchConceptsInterstitial Leydig cellsSteroidogenic enzymesLeydig cellsImmature male miceSerum testosterone concentrationsTesticular developmentInhibition of steroidogenesisCholesterol side-chain cleavage enzymeSide-chain cleavage enzymeSteroid hormone productionGerm cellsTesticular germ cellsApoptotic germ cellsOral gavageMale miceSingle administrationTestosterone concentrationsHormone productionInhibitory effectSeminiferous tubulesAdverse effectsInduced apoptosisTBT exposureAcute toxicityCleavage enzyme
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