Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study
Olbrich L, Franckling-Smith Z, Larsson L, Sabi I, Ntinginya N, Khosa C, Banze D, Nliwasa M, Corbett E, Semphere R, Verghese V, Michael J, Ninan M, Saathoff E, McHugh T, Razid A, Graham S, Song R, Nabeta P, Trollip A, Nicol M, Hoelscher M, Geldmacher C, Heinrich N, Zar H, consortium R, Dalgarno C, Mtafya B, Mwambola H, Manyama C, Sudi L, Sichone E, Mapamba D, Olomi W, Edwin P, Chacko A, Kumari R, Krishnan D, Munisamy N, Mani D, Maueia C, Madeira C, Kachere D, Chinoko T, Sikwese T, Mnyanga A, Chiume L, Mantsoki A, Baard C, Munro J, Prins M, Benzi N, Bateman L, Ryan A, Booi K, Paulo N, Heydenrych A, Petersen W, Brookes R, Mento M, Centner C. Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study. The Lancet Infectious Diseases 2024, 25: 188-197. PMID: 39312914, DOI: 10.1016/s1473-3099(24)00494-8.Peer-Reviewed Original ResearchMicrobiological confirmationInduced sputumSpontaneous sputumM tuberculosisSecondary analysisMicrobiological resultsGerman Center for Infection ResearchAnti-tuberculosis medicationsXpert MTB/RIF UltraHigh-risk subgroupsDiagnostic accuracy studiesSpecimen typesHealth-care centresUK Medical Research CouncilMiddle-income countriesNasopharyngeal aspiratesExtrapulmonary tuberculosisMedian agePaediatric tuberculosisPositive culturesGastric aspiratesSputumLowenstein-JensenMedical Research CouncilChoice of testsUtility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting
Randall P, Mutsvangwa J, Nliwasa M, Wilson L, Makamure B, Makambwa E, Meldau R, Dheda K, Munyati S, Siddiqi O, Corbett E, Esmail A. Utility of Cerebrospinal Fluid Unstimulated Interferon-Gamma (IRISA-TB) as a Same-Day Test for Tuberculous Meningitis in a Tuberculosis-Endemic, Resource-Poor Setting. Open Forum Infectious Diseases 2024, 11: ofae496. PMID: 39286031, PMCID: PMC11403475, DOI: 10.1093/ofid/ofae496.Peer-Reviewed Original ResearchUnstimulated interferon-gammaTuberculous meningitisPolymerase chain reaction productsCerebrospinal fluidXpert UltraDNA-based assaysInterferon-gammaHuman immunodeficiency virus (HIV)-infectedSuspected TBM patientsRule-in testPositive predictive valueGeneXpert UltraStage 2 evaluationTBM patientsSame-day testingNon-TBMZambian samplesUninfected participantsDiagnostic performanceAfrican samplesImmunodiagnostic assaysXpertMicrobiological resultsAssayBiobank samples
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