2013
Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer
Siddle H, Kreiss A, Tovar C, Yuen C, Cheng Y, Belov K, Swift K, Pearse A, Hamede R, Jones M, Skjødt K, Woods G, Kaufman J. Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 5103-5108. PMID: 23479617, PMCID: PMC3612627, DOI: 10.1073/pnas.1219920110.Peer-Reviewed Original ResearchConceptsDFTD cellsDown-regulation of MHC moleculesMHC class I moleculesClass I moleculesDevil facial tumour diseaseExpression of MHC class I moleculesI moleculesMHC moleculesTumor diseaseMHC class II transactivatorAssociated with up-regulationIn vivoClass II transactivatorTransporter associated with antigen processingLoss of gene expressionCells in vitroDown-regulationAntigen processing pathwayHost immune responseFacial tumour diseaseContagious cancerImmune escapeUnusual pathogenLymphocytic infiltrationT cells
1997
Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells.
Fikrig E, Barthold SW, Chen M, Chang CH, Flavell RA. Protective antibodies develop, and murine Lyme arthritis regresses, in the absence of MHC class II and CD4+ T cells. The Journal Of Immunology 1997, 159: 5682-6. PMID: 9548512, DOI: 10.4049/jimmunol.159.11.5682.Peer-Reviewed Original ResearchConceptsMHC class IIT cellsClass IINaive C3H/HeN miceC3H/HeN miceC57/BL6 miceCIITA-deficient miceRegression of arthritisResolution of arthritisResolution of carditisDevelopment of arthritisMurine Lyme borreliosisMHC class II transactivatorClass II moleculesClass II transactivatorIgG2b AbsProtective antibodiesBL6 miceHeN miceDeficient miceProtective AbsSCID micePersistent infectionArthritisCD4 repertoire
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