Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis
Kim Y, Mavodza G, Senkal C, Burd C. Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesis. Journal Of Cell Biology 2023, 222: e202308055. PMID: 37787764, PMCID: PMC10547602, DOI: 10.1083/jcb.202308055.Peer-Reviewed Original ResearchConceptsPlasma membraneEpidermal growth factor receptor signalingMembrane lipid homeostasisGrowth factor receptor signalingAcute cholesterol depletionCellular cholesterol homeostasisPlasma membrane cholesterol contentCellular cholesterol levelsMembrane lipid packingSterol-responsive elementMembrane cholesterol contentProtein translationCytoplasmic leafletCholesterol depletionSphingolipid synthesisGolgi apparatusProtein pathwayResponsive elementLipid homeostasisRegulatory axisReceptor signalingLysosome membraneSphingomyelin synthesisAccumulation of cholesterolMetabolic axisUridine-derived ribose fuels glucose-restricted pancreatic cancer
Nwosu Z, Ward M, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar R, Andren A, Apiz-Saab J, Tolstyka Z, Brown K, Lee H, Dzierozynski L, He X, PS H, Ugras J, Nyamundanda G, Zhang L, Halbrook C, Carpenter E, Shi J, Shriver L, Patti G, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis C. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature 2023, 618: 151-158. PMID: 37198494, PMCID: PMC10232363, DOI: 10.1038/s41586-023-06073-w.Peer-Reviewed Original ResearchConceptsUridine phosphorylase 1Pancreatic ductal adenocarcinomaExpression of uridine phosphorylase 1Central carbon metabolismPDA cellsGlucose-deprived conditionsBlunted tumor growthUridine utilizationImmunocompetent mouse modelPDAC therapyCohort of patientsCarbon metabolismNutrient restrictionPancreatic ductal adenocarcinoma cellsPancreatic cell linesNon-tumor tissuesTumor microenvironmentMetabolic axisMetabolic processesDuctal adenocarcinomaTumor progressionPoor survivalRedox balanceTumor growthSpectrum of metabolites
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