The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes
Hume A, Collinson L, Hopkins C, Strom M, Barral D, Bossi G, Griffiths G, Seabra M. The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes. Traffic 2002, 3: 193-202. PMID: 11886590, DOI: 10.1034/j.1600-0854.2002.030305.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell NucleusCells, CulturedImmunoblottingMelanocytesMelanosomesMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMicroscopy, ElectronMicroscopy, FluorescenceMutationMyosin Type VProtein BiosynthesisProteinsrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsReverse Transcriptase Polymerase Chain ReactionSpleenSyndromeT-Lymphocytes, CytotoxicConceptsGene productsMyosin VaClasses of effector proteinsFunction of lysosome-related organellesLytic granulesPeripheral actin networkLysosome-related organellesLoss of function mutationsLocalized to melanosomesCytotoxic T lymphocytesTips of melanocyte dendritesGriscelli syndromeEffector proteinsActin networkPerinuclear clusteringT lymphocytesRab27aFunction mutationsImmunological synapseMyosinMelanocyte dendritesPromote recruitmentMelanosomesKill target cellsReduced levels
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