2025
Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses
Park H, Song D, Nguyen M, Palm N, Crawford J. Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses. ACS Chemical Biology 2025, 20: 1775-1782. PMID: 40577169, PMCID: PMC12372651, DOI: 10.1021/acschembio.5c00313.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsDownstream functional consequencesSmall moleculesHuman G protein-coupled receptorsRNA sequencing analysisFunctional small moleculesMelatonin receptor type 1AGut commensalsGut microbesSingle-cell RNA sequencing analysisSequence analysisUrea coreTryptamine moietyMethyl carbamateInhibitory concentrationGutGut tissueHalf-maximal inhibitory concentrationUncharacterized metabolitesBacterial cultureMelatonin receptorsSignal responseMoleculesHuman physiologyScreening analysis
2016
The reduction in circulating levels of melatonin may be associated with the development of preeclampsia
Zeng K, Gao Y, Wan J, Tong M, Lee A, Zhao M, Chen Q. The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. Journal Of Human Hypertension 2016, 30: 666-671. PMID: 27251079, DOI: 10.1038/jhh.2016.37.Peer-Reviewed Original ResearchConceptsIncidence of preeclampsiaLevels of melatoninDevelopment of preeclampsiaSerum levelsPreeclamptic placentasMelatonin receptorsLate-onset preeclampsiaHealthy pregnant womenPregnancy-specific disorderPathogenesis of preeclampsiaHealthy pregnancyPlacental dysfunctionPregnant womenSuccessful pregnancyPreeclampsiaMelatonin levelsPregnancyIncidenceMelatoninOxidative stressWomenTime onsetPlacentaReceptorsAssociation
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