Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses
Park H, Song D, Nguyen M, Palm N, Crawford J. Tryptamine Metabolism and Functionalization in Gut Commensal Bacteria Expand Human Tryptamine Signaling Responses. ACS Chemical Biology 2025, 20: 1775-1782. PMID: 40577169, PMCID: PMC12372651, DOI: 10.1021/acschembio.5c00313.Peer-Reviewed Original ResearchConceptsG protein-coupled receptorsDownstream functional consequencesSmall moleculesHuman G protein-coupled receptorsRNA sequencing analysisFunctional small moleculesMelatonin receptor type 1AGut commensalsGut microbesSingle-cell RNA sequencing analysisSequence analysisUrea coreTryptamine moietyMethyl carbamateInhibitory concentrationGutGut tissueHalf-maximal inhibitory concentrationUncharacterized metabolitesBacterial cultureMelatonin receptorsSignal responseMoleculesHuman physiologyScreening analysis
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