2014
Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study
Nabili M, Shenoy A, Chawla S, Mahesh S, Liu J, Geist C, Zderic V. Ultrasound-enhanced ocular delivery of dexamethasone sodium phosphate: an in vivo study. Journal Of Therapeutic Ultrasound 2014, 2: 6. PMID: 24921047, PMCID: PMC4036608, DOI: 10.1186/2050-5736-2-6.Peer-Reviewed Original ResearchDexamethasone sodium phosphateAqueous humor samplesUnique anatomyDrug concentrationsSham-treated samplesVivo studiesOcular drug deliveryEye cupRabbit modelClinical settingAnatomical barriersOcular drugsHistological analysisOphthalmic drugsSodium phosphateResultsAn increaseCorneaEpithelial disorganizationEffective drug deliveryDrug deliveryOcular deliveryDrugsUltrasoundDeliveryMin
2005
Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and Glaucoma
Schlötzer-Schrehardt U, Zenkel M, Decking U, Haubs D, Kruse FE, Jünemann A, Coca-Prados M, Naumann GO. Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and Glaucoma. Investigative Ophthalmology & Visual Science 2005, 46: 2023-2034. PMID: 15914619, DOI: 10.1167/iovs.04-0915.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAgedAged, 80 and overAnterior Eye SegmentAqueous HumorBlotting, NorthernCell Culture TechniquesChromatography, High Pressure LiquidExfoliation SyndromeGlaucoma, Angle-ClosureGlaucoma, Open-AngleHumansHypoxanthineImmunohistochemistryIn Situ HybridizationInosineReceptor, Adenosine A3Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerUp-RegulationXanthineConceptsControl eyesLevels of adenosineA3 adenosine receptorAdenosine receptorsPEX eyesPseudoexfoliation syndromeIntraocular pressureAqueous humor secretionCiliary epitheliumEpithelial cellsNonpigmented epithelial cellsOxidative stressGlaucomatous control eyesAngle-closure glaucomaNormal control eyesHypoxia-induced upregulationAdenosine receptor expressionAqueous humor samplesAnterior segment tissuesAqueous humor dynamicsNonpigmented ciliary epitheliumA3 receptor mRNAEffects of hypoxiaAdenosine receptor subtypesNonpigmented ciliary epithelial cells
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