2005
Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and Glaucoma
Schlötzer-Schrehardt U, Zenkel M, Decking U, Haubs D, Kruse FE, Jünemann A, Coca-Prados M, Naumann GO. Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and Glaucoma. Investigative Ophthalmology & Visual Science 2005, 46: 2023-2034. PMID: 15914619, DOI: 10.1167/iovs.04-0915.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAgedAged, 80 and overAnterior Eye SegmentAqueous HumorBlotting, NorthernCell Culture TechniquesChromatography, High Pressure LiquidExfoliation SyndromeGlaucoma, Angle-ClosureGlaucoma, Open-AngleHumansHypoxanthineImmunohistochemistryIn Situ HybridizationInosineReceptor, Adenosine A3Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerUp-RegulationXanthineConceptsControl eyesLevels of adenosineA3 adenosine receptorAdenosine receptorsPEX eyesPseudoexfoliation syndromeIntraocular pressureAqueous humor secretionCiliary epitheliumEpithelial cellsNonpigmented epithelial cellsOxidative stressGlaucomatous control eyesAngle-closure glaucomaNormal control eyesHypoxia-induced upregulationAdenosine receptor expressionAqueous humor samplesAnterior segment tissuesAqueous humor dynamicsNonpigmented ciliary epitheliumA3 receptor mRNAEffects of hypoxiaAdenosine receptor subtypesNonpigmented ciliary epithelial cells
2003
Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway
Blackburn MR, Lee CG, Young HW, Zhu Z, Chunn JL, Kang MJ, Banerjee SK, Elias JA. Adenosine mediates IL-13–induced inflammation and remodeling in the lung and interacts in an IL-13–adenosine amplification pathway. Journal Of Clinical Investigation 2003, 112: 332-344. PMID: 12897202, PMCID: PMC166289, DOI: 10.1172/jci16815.Peer-Reviewed Original ResearchConceptsIL-13-induced inflammationIL-13Adenosine receptorsAdenosine accumulationIL-13-induced tissue responsesADA enzyme therapyIL-13 overexpressionTh2-mediated disordersIL-13-induced increaseAmplification pathwayAdenosine deaminase activityLevels of adenosineA2A adenosine receptorsAlveolar destructionRespiratory failureMurine lungEnzyme therapyADA activityRemodeling responseImportant mediatorInflammationLungReceptorsProgressive increaseTissue response
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