2020
Molecular “omic” signatures in systemic sclerosis
Mehta BK, Department of Molecular and Systems Biology G, Espinoza M, Hinchcliff M, Whitfield M, Department of Rheumatology A, Department of Biomedical Data Science D. Molecular “omic” signatures in systemic sclerosis. European Journal Of Rheumatology 2020, 7: 173-180. PMID: 33164732, PMCID: PMC7647683, DOI: 10.5152/eurjrheum.2020.19192.Peer-Reviewed Original ResearchDeregulated molecular pathwaysEpigenomic dataExtracellular matrix abnormalitiesMolecular pathwaysTiming of activationDisease phenotypeObserved clinical heterogeneityOmicsSSc researchMatrix abnormalitiesTranscriptomicsUnique insightsPhenotypePathwayPrecision medicineImportant stepActivationClinical heterogeneityIdentification
2019
Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes
Sewanan LR, Schwan J, Kluger J, Park J, Jacoby DL, Qyang Y, Campbell SG. Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes. JACC Basic To Translational Science 2019, 4: 495-505. PMID: 31468004, PMCID: PMC6712054, DOI: 10.1016/j.jacbts.2019.03.004.Peer-Reviewed Original ResearchHypertrophic cardiomyopathySarcomeric gene mutationsMiniature swine modelPluripotent stem cell-derived cardiomyocytesExtracellular matrix abnormalitiesStem cell-derived cardiomyocytesPoor relaxationCell-derived cardiomyocytesHealthy cardiomyocytesExtracellular matrixMouse modelPharmacological correctionProlonged contractionSwine modelHealthy extracellular matrixMuscle contractionGene mutationsMatrix abnormalitiesTwitch dynamicsCardiomyocytesContractionCardiomyopathyTherapyMyocardiumAbnormalities
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