2024
Validation of Metallothionein Immunohistochemistry as a Highly Sensitive Screening Test for Wilson Disease
Stokes N, Patil A, Adeyi O, Bhalla A, Brown I, Byrnes K, Calderaro J, Chen D, Chen W, Cooper C, Dhall D, Frankel W, Gooch G, Gonzalez R, Hammer S, Hale G, Lagana S, McKenzie C, Allende D, Moreira R, Nakhleh R, Nalbantoglu I, Pai R, Salomao M, Schaeffer D, Shih A, Shin J, Simoes C, Vij M, Rela M, Xue Y, Yantiss R, Sabatto B, Graham R. Validation of Metallothionein Immunohistochemistry as a Highly Sensitive Screening Test for Wilson Disease. Modern Pathology 2024, 38: 100628. PMID: 39384020, DOI: 10.1016/j.modpat.2024.100628.Peer-Reviewed Original ResearchWilson's diseaseHistological featuresRare autosomal recessive conditionChronic cholestatic diseaseProtean clinical manifestationsEvaluation of patientsAutosomal recessive conditionSensitive screening testCase of WDCost-effective screening toolRoutine histologic sectionsMedian ageNeedle biopsyCholestatic diseasesWD patientsFibrosis stageClinical manifestationsHistopathological patternsATP7B mutationsHistological patternWD diagnosisTissue specimensAssessed patientsImmunohistochemistryMasson's trichrome
2003
Role of Interstitial Cells of Cajal in Motility Disorders of the Bowel
Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of Interstitial Cells of Cajal in Motility Disorders of the Bowel. The American Journal Of Gastroenterology 2003, 98: ajg2003146. PMID: 12650797, DOI: 10.1111/j.1572-0241.2003.07295.x.Peer-Reviewed Original ResearchConceptsMechanical bowel obstructionMotility disordersBowel obstructionNormal controlsInterstitial cellsPolyclonal c-kit antibodyAge-matched normal controlsBowel motility disordersNeonatal meconium ileusSpecific histological changesAdministration of drugsIndirect immunoperoxidase methodC-kit antibodyBowel dysmotilityMechanical obstructionSystemic disordersMeconium ileusC-kit receptorHistological changesNeuropathic formPatientsPatchy areasImmunoperoxidase methodMasson's trichromeIntestinal tract
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