Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments
Coskun S, Hirschi KK. Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Research Part C Embryo Today Reviews 2010, 90: 229-242. PMID: 21181885, PMCID: PMC5226239, DOI: 10.1002/bdrc.20194.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsAdult bone marrow nichesExtraembryonic yolk sacVascular endothelial cellsAdult bone marrowBone marrow nicheMammalian embryogenesisHSC formationBlood cell typesHematopoiesis changeAorta-gonadHSC generationMesonephros (AGM) regionHSC maturationMajor regulatory factorLifelong supplyMajor cellular componentHSC nicheEndothelial cellsMulti-potent cellsRegulatory factorsCellular componentsCell typesMarrow nicheDifferent tissues
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