2023
Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
Ghersi J, Baldissera G, Hintzen J, Luff S, Cheng S, Xia I, Sturgeon C, Nicoli S. Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium. Nature Cell Biology 2023, 25: 1135-1145. PMID: 37460694, PMCID: PMC10415179, DOI: 10.1038/s41556-023-01187-9.Peer-Reviewed Original ResearchConceptsHaemogenic endothelial cellsHaematopoietic stemPost-transcriptional repressionHuman pluripotent stem cellsProgenitor cell heterogeneityCell cycle statePluripotent stem cellsG2/MZebrafish leadsAorta-gonadBlood lineagesEmbryonic endotheliumExpansion of HSPCsEndothelial cellsProliferative outputDifferent cell cycle statesLymphoid progenitorsCell heterogeneityLineagesMiR-128Jag1bHSPCsMyeloid lineageStem cellsCycle state
2015
Vascular Niche in HSC Development, Maintenance and Regulation
Coşkun S, Hirschi K. Vascular Niche in HSC Development, Maintenance and Regulation. Stem Cell Biology And Regenerative Medicine 2015, 191-219. DOI: 10.1007/978-3-319-21705-5_9.Peer-Reviewed Original ResearchVascular nicheVascular niche cellsExtraembryonic yolk sacStem cellsBlood cell lineagesHSC ontogenyMammalian embryogenesisAorta-gonadHSC developmentHSC maintenanceMesonephros (AGM) regionHematopoietic stem cellsCellular phenotypesNiche cellsMolecular basisNiche compositionCell lineagesMulti-potent cellsNiche typesExtracellular matrixNicheYolk sacVascular cellsUnique microenvironmentFetal liver
2010
Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments
Coskun S, Hirschi KK. Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Research Part C Embryo Today Reviews 2010, 90: 229-242. PMID: 21181885, PMCID: PMC5226239, DOI: 10.1002/bdrc.20194.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsAdult bone marrow nichesExtraembryonic yolk sacVascular endothelial cellsAdult bone marrowBone marrow nicheMammalian embryogenesisHSC formationBlood cell typesHematopoiesis changeAorta-gonadHSC generationMesonephros (AGM) regionHSC maturationMajor regulatory factorLifelong supplyMajor cellular componentHSC nicheEndothelial cellsMulti-potent cellsRegulatory factorsCellular componentsCell typesMarrow nicheDifferent tissues
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