2016
Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway
Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V. Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway. Scientific Reports 2016, 6: 29743. PMID: 27403993, PMCID: PMC4940737, DOI: 10.1038/srep29743.Peer-Reviewed Original ResearchConceptsAlcoholic liver diseaseGclm KO miceLiver steatosisKO miceAlcohol-induced liver steatosisFactor 2 (Nrf2) target genesEthanol-containing liquid dietOxidative stressGclm knockout mouseAlcohol-induced steatosisHepatic lipid profilesProtein kinase pathwayNew therapeutic strategiesNormal hepatic levelsLevels of glutathioneFatty acid oxidationKinase pathwayLiver diseaseLipid profileLiquid dietEthanol clearanceHepatic levelsTherapeutic strategiesKnockout miceSteatosis
2000
Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice
Dai J, Lin D, Zhang J, Habib P, Smith P, Murtha J, Fu Z, Yao Z, Qi Y, Keller E. Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice. Journal Of Clinical Investigation 2000, 106: 887-895. PMID: 11018077, PMCID: PMC381425, DOI: 10.1172/jci10483.Peer-Reviewed Original ResearchConceptsReceptor activator of NF-kappaB ligandCFU-GM formationIL-6CFU-GMEthanol ingestionBone lossIL-6 gene knockoutReceptor activationDual-energy densitometryBone marrow cell culturesChronic alcohol ingestionBone mineral densityEthanol liquid dietCancellous bone volumeMarrow cell culturesNF-kappaB ligandUrinary deoxypyridinolineOsteoblast parametersOsteoclast surfaceMineral densityAlcohol ingestionBone marrowLiquid dietBone remodeling parametersBone volume
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