2025
Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes
Awuoche E, Smallenberger G, Bruzzese D, Orfano A, Weiss B, Aksoy S. Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes. PLOS Pathogens 2025, 21: e1012692. PMID: 39888974, PMCID: PMC11819587, DOI: 10.1371/journal.ppat.1012692.Peer-Reviewed Original ResearchConceptsHost physiologyInsect stage procyclic formsPrevent gut colonizationHigh-throughput RNA sequencingHost-pathogen dynamicsImmunity-related genesInfluence of microbiotaReduced lipid availabilitySubgroup speciesPresence of SpiroplasmaLipid biosynthesisExpression regulationGut colonizationGut environmentMicrobiota compositionProcyclic formsSpiroplasma infectionEscherichia coliRNA sequencingLipid synthesisTrypanosoma brucei parasitesInfection processSpiroplasmaGenetic traitsAfrican trypanosomes
2023
Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis
Attardo G, Benoit J, Michalkova V, Kondragunta A, Baumann A, Weiss B, Malacrida A, Scolari F, Aksoy S. Lipid metabolism dysfunction following symbiont elimination is linked to altered Kennedy pathway homeostasis. IScience 2023, 26: 107108. PMID: 37534171, PMCID: PMC10391724, DOI: 10.1016/j.isci.2023.107108.Peer-Reviewed Original ResearchKennedy pathwayObligate endosymbiotic bacteriaViviparous tsetse flyLipid metabolismEarly developmental stagesInsect reproductionEndosymbiotic bacteriaSymbiotic bacteriaLipid biosynthesisPathway homeostasisSymbiont eliminationFunctional validationExperimental removalPhosphatidylcholine biosynthesisDevelopmental stagesProper functionTsetse fliesBiosynthesisLipid metabolism dysfunctionImpaired lipid metabolismMetabolismBacteriaPathwayMetabolism dysfunctionSymbionts
2016
Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells
Yasumoto Y, Miyazaki H, Vaidyan LK, Kagawa Y, Ebrahimi M, Yamamoto Y, Ogata M, Katsuyama Y, Sadahiro H, Suzuki M, Owada Y. Inhibition of Fatty Acid Synthase Decreases Expression of Stemness Markers in Glioma Stem Cells. PLOS ONE 2016, 11: e0147717. PMID: 26808816, PMCID: PMC4726602, DOI: 10.1371/journal.pone.0147717.Peer-Reviewed Original ResearchConceptsFatty acid synthaseGlioma stem cellsStem cellsCellular lipid metabolismCellular metabolic changesKey lipogenic enzymesPatient-derived glioma stem cellsLipid biosynthesisFatty acid binding proteinAcid binding proteinPharmacological inhibitorsSynthesis assayBinding proteinAcid synthaseCerulenin treatmentGlial fibrillary acidic protein (GFAP) expressionGSC stemnessProtein expressionCancer cellsDe novo lipogenesisLipogenic enzymesImmunocytochemical analysisMarker nestinStemness markersDecrease expression
2013
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Williams K, Argus J, Zhu Y, Wilks M, Marbois B, York A, Kidani Y, Pourzia A, Akhavan D, Lisiero D, Komisopoulou E, Henkin A, Soto H, Chamberlain B, Vergnes L, Jung M, Torres J, Liau L, Christofk H, Prins R, Mischel P, Reue K, Graeber T, Bensinger S. An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity. Cancer Research 2013, 73: 2850-2862. PMID: 23440422, PMCID: PMC3919498, DOI: 10.1158/0008-5472.can-13-0382-t.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell Line, TumorCell ProliferationFatty Acid SynthasesGene Expression ProfilingGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Inbred NODModels, StatisticalNeoplasm TransplantationNeoplasmsSignal TransductionStearoyl-CoA DesaturaseSterolsConceptsSterol regulatory element-binding proteinsFatty acid synthesisSREBP activityCellular growthFatty acid poolKey transcriptional regulatorCancer cellsFatty acid desaturationAcid synthesisAcid poolElement-binding proteinMetabolic flux analysisTranscriptional regulatorsLipid biosynthesisNovel mechanistic explanationStearoyl-CoA desaturase-1Fatty acid synthase activityCancer metabolismCancer cell growthSignaling AxisCell growthFlux analysisSynthase activityDesaturase 1Lipid profiling
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