Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes
Awuoche E, Smallenberger G, Bruzzese D, Orfano A, Weiss B, Aksoy S. Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes. PLOS Pathogens 2025, 21: e1012692. PMID: 39888974, PMCID: PMC11819587, DOI: 10.1371/journal.ppat.1012692.Peer-Reviewed Original ResearchConceptsHost physiologyInsect stage procyclic formsPrevent gut colonizationHigh-throughput RNA sequencingHost-pathogen dynamicsImmunity-related genesInfluence of microbiotaReduced lipid availabilitySubgroup speciesPresence of SpiroplasmaLipid biosynthesisExpression regulationGut colonizationGut environmentMicrobiota compositionProcyclic formsSpiroplasma infectionEscherichia coliRNA sequencingLipid synthesisTrypanosoma brucei parasitesInfection processSpiroplasmaGenetic traitsAfrican trypanosomes
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