2023
Functionally and Metabolically Divergent Melanoma-Associated Macrophages Originate from Common Bone-Marrow Precursors
Pizzurro G, Bridges K, Jiang X, Vidyarthi A, Miller-Jensen K, Colegio O. Functionally and Metabolically Divergent Melanoma-Associated Macrophages Originate from Common Bone-Marrow Precursors. Cancers 2023, 15: 3330. PMID: 37444440, PMCID: PMC10341323, DOI: 10.3390/cancers15133330.Peer-Reviewed Original ResearchGene Set Enrichment AnalysisBone marrow precursorsTissue-specific nichesTumor-associated macrophagesMelanoma tumor microenvironmentTranscriptomic analysisRNA sequencingTumor microenvironmentEnrichment analysisOxidative phosphorylationProtein secretionTemporal divergenceCanonical markersPolyamine metabolismTAM subsetsLike phenotypeSkin-resident macrophagesMacrophage phenotypeMonocytic precursorsOntogenyTumor progressionDepth characterizationPhenotypeMacrophage subsetsTAM subpopulations
2010
A transient epidermolysis bullosa simplex‐like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote
Trufant JW, Kreizenbeck GM, Carlson KR, Muthusamy V, Girardi M, Bosenberg MW. A transient epidermolysis bullosa simplex‐like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote. Journal Of Cutaneous Pathology 2010, 37: 1155-1160. PMID: 20849457, DOI: 10.1111/j.1600-0560.2010.01557.x.Peer-Reviewed Original ResearchConceptsBexarotene treatmentEpidermolysis bullosa simplexKeratinocyte lysisCutaneous T-cell lymphomaT-cell lymphomaPalmoplantar keratodermaIntraepidermal blister formationClinical subtypesClinical trialsDrug treatmentSide effectsMechanobullous disordersReticulate hyperpigmentationSkin fragilityLike phenotypeKeratin 5Genetic sequencingSimilar frequencyRare variantsFocal palmoplantar keratodermaBlister formationTreatmentKRT5 mutationKeratin synthesisKeratoderma
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