2019
Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage
Chang CF, Massey J, Osherov A, Angenendt da Costa LH, Sansing LH. Bexarotene Enhances Macrophage Erythrophagocytosis and Hematoma Clearance in Experimental Intracerebral Hemorrhage. Stroke 2019, 51: 612-618. PMID: 31826730, PMCID: PMC7135897, DOI: 10.1161/strokeaha.119.027037.Peer-Reviewed Original ResearchConceptsIntracerebral hemorrhageBexarotene treatmentFunctional recoveryHematoma clearanceRetinoid X receptor agonistExperimental intracerebral hemorrhageX receptor agonistMacrophage TNF productionMarrow-derived macrophagesNeurological recoveryNeurobehavioral recoveryNeurological deficitsAutologous bloodBrain recoveryHematoma volumeReceptor agonistTherapeutic effectMacrophage expressionTNF productionMouse modelVivo phagocytosisMacrophage phenotypeFlow cytometryHistological analysisErythrocyte metabolites
2010
A transient epidermolysis bullosa simplex‐like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote
Trufant JW, Kreizenbeck GM, Carlson KR, Muthusamy V, Girardi M, Bosenberg MW. A transient epidermolysis bullosa simplex‐like phenotype associated with bexarotene treatment in a G138E KRT5 heterozygote. Journal Of Cutaneous Pathology 2010, 37: 1155-1160. PMID: 20849457, DOI: 10.1111/j.1600-0560.2010.01557.x.Peer-Reviewed Original ResearchConceptsBexarotene treatmentEpidermolysis bullosa simplexKeratinocyte lysisCutaneous T-cell lymphomaT-cell lymphomaPalmoplantar keratodermaIntraepidermal blister formationClinical subtypesClinical trialsDrug treatmentSide effectsMechanobullous disordersReticulate hyperpigmentationSkin fragilityLike phenotypeKeratin 5Genetic sequencingSimilar frequencyRare variantsFocal palmoplantar keratodermaBlister formationTreatmentKRT5 mutationKeratin synthesisKeratoderma
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