2024
Spatiotemporal Organization of Prefrontal Norepinephrine Influences Neuronal Activity
Glaeser-Khan S, Savalia N, Cressy J, Feng J, Li Y, Kwan A, Kaye A. Spatiotemporal Organization of Prefrontal Norepinephrine Influences Neuronal Activity. ENeuro 2024, 11: eneuro.0252-23.2024. PMID: 38702188, PMCID: PMC11134306, DOI: 10.1523/eneuro.0252-23.2024.Peer-Reviewed Original ResearchTwo-photon imagingLocus coeruleusPrefrontal cortexOptical flow analysisIn vivo two-photon imagingInfluence neuronal activityVesicle exocytosisControl of cortical activityNE releaseGPCR-based sensorsNE dynamicsLocal fieldNeuronal calciumNeuronal firingCell firingNE roleNorepinephrineHomogeneous fieldNeuronal activitySpatiotemporal activity patternsNeurotransmitter functionSensorLight-sheet imagingAxonal dynamicsSpatial scales
2022
JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga M, Zhou Z, Canham L, Roddie H, Pirri D, Chambers E, Dunning M, Ariaans M, Li J, Fang Y, Jørgensen H, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis S, Chico T, Serbanovic-Canic J, Evans P. JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances 2022, 8: eabo7958. PMID: 36044575, PMCID: PMC9432841, DOI: 10.1126/sciadv.abo7958.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingRNA sequencingNotch pathwaySignaling pathwaySubsets of endothelial cellsAtherosclerosis susceptibilityEndothelial cellsGenetic deletionCultured human coronary artery ECPathwayTherapeutic targetLight-sheet imagingBlood vessel growthArtery ECCoronary artery ECHuman coronary artery EC
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