JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Tardajos Ayllon B, Li X, Diagbouga M, Zhou Z, Canham L, Roddie H, Pirri D, Chambers E, Dunning M, Ariaans M, Li J, Fang Y, Jørgensen H, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis S, Chico T, Serbanovic-Canic J, Evans P. JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances 2022, 8: eabo7958. PMID: 36044575, PMCID: PMC9432841, DOI: 10.1126/sciadv.abo7958.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingRNA sequencingNotch pathwaySignaling pathwaySubsets of endothelial cellsAtherosclerosis susceptibilityEndothelial cellsGenetic deletionCultured human coronary artery ECPathwayTherapeutic targetLight-sheet imagingBlood vessel growthArtery ECCoronary artery ECHuman coronary artery EC
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