2019
Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis
Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 18517-18527. PMID: 31455730, PMCID: PMC6744919, DOI: 10.1073/pnas.1904271116.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsArthritis, ExperimentalArthritis, RheumatoidBiopsyCD4-Positive T-LymphocytesCell DifferentiationDown-RegulationFemaleGenes, ReporterGreen Fluorescent ProteinsHumansInterleukin-17Interleukin-6MaleMiceMice, TransgenicMiddle AgedNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Antigen, T-CellSignal TransductionSuppressor of Cytokine Signaling 3 ProteinSynovectomySynovial MembraneTh17 CellsZymosanConceptsCD4 T cellsRheumatoid arthritisT cellsSKG miceAutoimmune arthritisDifferentiation 4 (CD4) T cellsReceptor signalingHuman autoimmune arthritisIL-6 receptor signalingSKG mouse modelAutoreactive T cellsArthritogenic T cellsIL-6 cytokinesTCR signalingIL-6 signalingRA synoviumSuppressor of cytokineArthritogenic potentialInterleukin-17IL-6Autoantigen exposureEnhanced autoreactivityMouse modelAntigen receptor signalingNur77-eGFP
1998
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
Holsinger L, Graef I, Swat W, Chi T, Bautista D, Davidson L, Lewis R, Alt F, Crabtree G. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Current Biology 1998, 8: 563-573. PMID: 9601640, DOI: 10.1016/s0960-9822(98)70225-8.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell Cycle ProteinsCytoskeletonDNA-Binding ProteinsHumansJurkat CellsMiceNFATC Transcription FactorsNuclear ProteinsProto-Oncogene ProteinsProto-Oncogene Proteins c-vavReceptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellSignal TransductionT-LymphocytesTranscription FactorsTranscription, GeneticConceptsMitogen-activated protein kinaseCap formationActin polymerizationGuanine nucleotide exchange factorsJun N-terminal kinaseTranscription factor NF-ATc1Vav-deficient miceActin-dependent pathwayStress-activated kinasesGrowth regulatory signalsActin cap formationAntigen receptor signalingEgr-1 geneLymphocyte signal transductionN-terminal kinaseAntigen-receptor interactionActin cytoskeletonExchange factorTranscriptional inductionSignal transductionDependent transcriptionProtein kinaseGTPase RacRegulatory signalsNull mutation
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