Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction.
Rosenthal S, Feldman B, Vargas G, Gitelman S. Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction. Pediatric Endocrinology Reviews : PER 2006, 4 Suppl 1: 66-70. PMID: 17261972.Peer-Reviewed Original ResearchConceptsActivating mutationsLevels of arginine vasopressinMutations of G protein-coupled receptorsAntidiuretic hormone secretionNephrogenic diabetes insipidusV2 vasopressin receptorNephrogenic syndromeV2R mutationsDiabetes insipidusArginine vasopressinClinical presentationAntidiuretic hormoneVasopressin signalingG protein-coupled receptorsEndocrine dysfunctionVasopressin receptorsHormone secretionInactivating mutationsGain-of-functionUndetectable levelsNSIADVasopressinAntidiuresisMutationsPatients
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