2013
The tumor suppressor CDKN3 controls mitosis
Nalepa G, Barnholtz-Sloan J, Enzor R, Dey D, He Y, Gehlhausen J, Lehmann A, Park S, Yang Y, Yang X, Chen S, Guan X, Chen Y, Renbarger J, Yang F, Parada L, Clapp W. The tumor suppressor CDKN3 controls mitosis. Journal Of Cell Biology 2013, 201: 997-1012. PMID: 23775190, PMCID: PMC3691455, DOI: 10.1083/jcb.201205125.Peer-Reviewed Original ResearchConceptsLibrary of small interfering RNAsLocalizes to mitotic centrosomesGenome-wide setNetwork of kinasesSignaling AxisMass spectrometry screeningSmall interfering RNAEarly mitosisMitotic exitSubcellular localizationHuman phosphatasesSpindle checkpointMitotic centrosomesSerine 209Normal mitosisCell cycleG1/S transitionCDKN3MitosisTargeted anticancer therapeuticsDown-regulationCdc2CentrosomeAnticancer therapeuticsPhosphatase
2008
Structural basis for EGFR ligand sequestration by Argos
Klein DE, Stayrook SE, Shi F, Narayan K, Lemmon MA. Structural basis for EGFR ligand sequestration by Argos. Nature 2008, 453: 1271-1275. PMID: 18500331, PMCID: PMC2526102, DOI: 10.1038/nature06978.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell LineCrystallography, X-RayDrosophila melanogasterDrosophila ProteinsEpidermal Growth FactorErbB ReceptorsEye ProteinsHumansLigandsMembrane ProteinsModels, MolecularNerve Tissue ProteinsProtein Structure, TertiaryReceptors, Transforming Growth Factor betaSpodopteraConceptsEpidermal growth factor receptorLigand sequestrationEGFR ligand SpitzLigand SpitzMammalian counterpartsGrowth factor receptorStructural basisUrokinase plasminogen activatorStructural homologuesEGFR ligandsFactor receptorAnticancer therapeuticsStructural resemblanceHomologuesPlasminogen activatorReceptorsSequestrationProteinActivatorLigandsSpitzTGFTherapeuticsDomain
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