2008
Structural basis for EGFR ligand sequestration by Argos
Klein DE, Stayrook SE, Shi F, Narayan K, Lemmon MA. Structural basis for EGFR ligand sequestration by Argos. Nature 2008, 453: 1271-1275. PMID: 18500331, PMCID: PMC2526102, DOI: 10.1038/nature06978.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCell LineCrystallography, X-RayDrosophila melanogasterDrosophila ProteinsEpidermal Growth FactorErbB ReceptorsEye ProteinsHumansLigandsMembrane ProteinsModels, MolecularNerve Tissue ProteinsProtein Structure, TertiaryReceptors, Transforming Growth Factor betaSpodopteraConceptsEpidermal growth factor receptorLigand sequestrationEGFR ligand SpitzLigand SpitzMammalian counterpartsGrowth factor receptorStructural basisUrokinase plasminogen activatorStructural homologuesEGFR ligandsFactor receptorAnticancer therapeuticsStructural resemblanceHomologuesPlasminogen activatorReceptorsSequestrationProteinActivatorLigandsSpitzTGFTherapeuticsDomain
2001
Interleukin-1β Regulates Urokinase Plasminogen Activator (u-PA), u-PA Receptor, Soluble u-PA Receptor, and Plasminogen Activator Inhibitor-1 Messenger Ribonucleic Acid Expression in Cultured Human Endometrial Stromal Cells1
Chung H, Wen Y, Ahn J, Moon H, Polan M. Interleukin-1β Regulates Urokinase Plasminogen Activator (u-PA), u-PA Receptor, Soluble u-PA Receptor, and Plasminogen Activator Inhibitor-1 Messenger Ribonucleic Acid Expression in Cultured Human Endometrial Stromal Cells1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1332-1340. PMID: 11238529, DOI: 10.1210/jcem.86.3.7335.Peer-Reviewed Original ResearchMeSH KeywordsBinding, CompetitiveCells, CulturedCulture Media, ConditionedEndometriumEnzyme-Linked Immunosorbent AssayFemaleGene ExpressionHumansInterleukin-1Plasminogen Activator Inhibitor 1ProlactinReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSolubilityStromal CellsUrokinase-Type Plasminogen ActivatorConceptsU-PA receptorMessenger ribonucleic acidIL-1betaPAI-1Urokinase plasminogen activatorU-PAInterleukin-1Confluent stromal cell culturesMessenger ribonucleic acid dataPlasminogen activatorCultured human endometrial stromal cellsU-PA mRNA expressionMeasured PAI-1Messenger ribonucleic acid expressionStromal cell decidualizationHuman endometrial stromal cellsIL-1beta antibodyRibonucleic acid expressionU-PAR expressionStromal cell culturesAnti-IL-1betaPlasminogen activator inhibitorLocal intercellular interactionsTreated with progesteronePlasminogen activation system
1996
Role of plasminogen activator inhibitor in the reciprocal regulation of bovine aortic endothelial and smooth muscle cell migration by TGF-beta 1.
Petzelbauer E, Springhorn J, Tucker A, Madri J. Role of plasminogen activator inhibitor in the reciprocal regulation of bovine aortic endothelial and smooth muscle cell migration by TGF-beta 1. American Journal Of Pathology 1996, 149: 923-31. PMID: 8780396, PMCID: PMC1865168.Peer-Reviewed Original ResearchConceptsVascular cell typesCell typesSmooth muscle cellsPlasminogen activator inhibitorMuscle cellsAnti-catalytic antibodyActivator inhibitorExtracellular matrix componentsMigratory rateVascular smooth muscle cellsEndothelial cellsSmooth muscle cell migrationUrokinase plasminogen activatorMigratory behaviorReciprocal regulationMuscle cell migrationStable transfectantsCell migrationExtracellular matrixIntegrin synthesisMatrix componentsMigratory responseProteolytic phenotypeProteolytic activityGrowth factorIntegrin-dependent induction of functional urokinase receptors in primary T lymphocytes.
Bianchi E, Ferrero E, Fazioli F, Mangili F, Wang J, Bender J, Blasi F, Pardi R. Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes. Journal Of Clinical Investigation 1996, 98: 1133-1141. PMID: 8787676, PMCID: PMC507535, DOI: 10.1172/jci118896.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesBreast NeoplasmsCD18 AntigensCell MovementCyclic AMPFemaleFlow CytometryHumansImmunologic CappingIntegrin beta1Lymphocyte ActivationLymphocytes, Tumor-InfiltratingPancreatic NeoplasmsProtein Kinase CReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorRNA, MessengerSecond Messenger SystemsT-LymphocytesUrokinase-Type Plasminogen ActivatorConceptsUrokinase plasminogen activatorAntigen receptor complexProtein kinase C activationAnti-uPAR antibodiesPlasminogen activator/plasmin systemKinase C activationPrimary human tumor specimensRegulated processPrimary T lymphocytesHuman tumor specimensT lymphocytesT cellsUrokinase receptorCell migrationExtracellular matrixReceptor complexC activationProtein levelsSites of inflammationT cell migrationPlasminogen activationCatalytic activationIntracellular cyclic AMPPlasmin systemCyclic AMP
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