2019
Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it
Tedja R, Roberts CM, Alvero AB, Cardenas C, Yang-Hartwich Y, Spadinger S, Pitruzzello M, Yin G, Glackin CA, Mor G. Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it. Journal Of Biological Chemistry 2019, 294: 5082-5093. PMID: 30733340, PMCID: PMC6442047, DOI: 10.1074/jbc.ra118.005921.Peer-Reviewed Original ResearchConceptsProtein kinase CPhosphorylation sitesHelix transcription factorPhosphorylation of Twist1Candidate phosphorylation sitesProtein kinase CαCombination of immunoblottingUbiquitination eventsTwist1 phosphorylationTranscription factorsEmbryonic developmentKnockout experimentsSer-144CRISPR/Twist1 proteinKinase CInvasive phenotypeAdult cellsPhosphorylationTwist1UbiquitinationCancer developmentCell linesTwist1 expressionPKCα
2008
Genomic Androgen Receptor-Occupied Regions with Different Functions, Defined by Histone Acetylation, Coregulators and Transcriptional Capacity
Jia L, Berman BP, Jariwala U, Yan X, Cogan JP, Walters A, Chen T, Buchanan G, Frenkel B, Coetzee GA. Genomic Androgen Receptor-Occupied Regions with Different Functions, Defined by Histone Acetylation, Coregulators and Transcriptional Capacity. PLOS ONE 2008, 3: e3645. PMID: 18997859, PMCID: PMC2577007, DOI: 10.1371/journal.pone.0003645.Peer-Reviewed Original ResearchConceptsTranscription factorsChromatin immunoprecipitation-microarray analysisTarget gene expression levelsSame transcription factorHuman genomic DNAGene expression levelsChromatin structureSuch genesKnockout experimentsHistone acetylationTarget genesEnhancer activityTranscriptional capacityDNA locationsGenomic androgen receptorsGene expressionGenomic DNAMicroarray analysisProstate cancer cellsDifferential regulationGenesLuciferase reporterDiverse mechanismsHigh-throughput elucidationContinuous stretch
2007
Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse
Abe T, Kakehata S, Kitani R, Maruya S, Navaratnam D, Santos-Sacchi J, Shinkawa H. Developmental Expression of the Outer Hair Cell Motor Prestin in the Mouse. The Journal Of Membrane Biology 2007, 215: 49-56. PMID: 17415610, PMCID: PMC4154540, DOI: 10.1007/s00232-007-9004-5.Peer-Reviewed Original ResearchConceptsLateral membranesOuter hair cellsMouse outer hair cellsMotor protein activitySteady-state levelsKnockout experimentsProtein activityDevelopmental expressionMembrane tensionGenetic modificationConformational fluctuationsCellular mechanismsMotor moleculesMolecular motorsOnset of hearingMorphological estimatesProtein densityEarly maturationQuantitative polymerase chain reactionHair cellsVpkCmDevelopmental dataCochlear amplificationMaturationFull maturation
2002
Early Gonadal Development: Exploring Wt1 and Sox9 Function
Guo J, Hammes A, Chaboissier M, Vidal V, Xing Y, Wong F, Schedl A. Early Gonadal Development: Exploring Wt1 and Sox9 Function. Novartis Foundation Symposia 2002, 244: 23-34. PMID: 11990794, DOI: 10.1002/0470868732.ch3.Peer-Reviewed Original ResearchConceptsSox9 functionSex determinationSex-determining gene SRYSex-determining signalWilms' tumor suppressorFemale sex reversalBipotential primordiumGonad formationGene SRYXX gonadsTransgenic experimentsFirst geneGonadal primordiumMouse developmentPosttranscriptional modificationsKnockout experimentsSex reversalHuman SOX9Distinct functionsSRY geneGonadal anlageSOX9 geneTumor suppressorImportant regulatorGenes
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