Innate immune molecular landscape following controlled human influenza virus infection
Thistlethwaite W, Vangeti S, Cheng W, Agarwal P, Cappuccio A, Wang W, Wei B, Myers R, Rubenstein A, Chawla D, Hariharan M, McClain M, Burke T, Kleinstein S, Ecker J, Woods C, Greenleaf W, Chen X, Ramos I, Zaslavsky E, Evans T, Troyanskaya O, Sealfon S. Innate immune molecular landscape following controlled human influenza virus infection. Cell Reports 2025, 44: 116312. PMID: 40966076, DOI: 10.1016/j.celrep.2025.116312.Peer-Reviewed Original ResearchInfluenza virus infectionInnate immune cellsGene promoter regionImmune cellsHistone deacetylase gene expressionHuman influenza virus infectionMolecular landscapeVirus infectionComprehensive multi-omics analysisAP-1Gene expressionPromoter regionMulti-omics analysisAP-1 targetViral infectionKinase gene expressionBlood samplesImmunization programsProlonged changesCircuit activityMethylation remodelingInfectionChallenge studiesInnate immunityInflammation
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