2018
The role of ketoconazole in current prostate cancer care
Patel V, Liaw B, Oh W. The role of ketoconazole in current prostate cancer care. Nature Reviews Urology 2018, 15: 643-651. PMID: 30154429, DOI: 10.1038/s41585-018-0077-y.Peer-Reviewed Original ResearchConceptsCastration-resistant prostate cancerNonmetastatic castration-resistant prostate cancerMetastatic castration-resistant prostate cancerSecond-line therapyProstate cancer careAbiraterone acetateSurvival benefitTreatment landscapeProstate cancerImproved survivalTherapeutic optionsToxicity profileClinical efficacyOff-labelEffective treatmentChemotherapyQuality of lifeKetoconazoleSurvivalPatientsOptimal timingEfficacyCancer careEnzalutamideAbiraterone
2009
Activity of Dutasteride Plus Ketoconazole in Castration-Refractory Prostate Cancer After Progression on Ketoconazole Alone
Sartor O, Nakabayashi M, Taplin M, Ross R, Kantoff P, Balk S, Oh W. Activity of Dutasteride Plus Ketoconazole in Castration-Refractory Prostate Cancer After Progression on Ketoconazole Alone. Clinical Genitourinary Cancer 2009, 7: e90-e92. PMID: 19815488, DOI: 10.3816/cgc.2009.n.030.Peer-Reviewed Original ResearchConceptsCastration-refractory prostate cancerProstate-specific antigenProstate cancerMedian progression-free survivalProstate-specific antigen declineProstate-specific antigen progressionSecondary hormonal therapyProgression-free survivalDecline relative to baselineCombination of ketoconazoleMetastatic lesionsHormone therapyKetoconazole treatmentDisease progressionDutasteridePatientsKetoconazoleCancerMitigate progressionProgressionTreatmentTherapyLesionsAntigenMonths
2002
Ketoconazole increases cocaine and opioid use in methadone maintained patients
Kosten T, Oliveto A, Sevarino K, Gonsai K, Feingold A. Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug And Alcohol Dependence 2002, 66: 173-180. PMID: 11906804, DOI: 10.1016/s0376-8716(01)00198-3.Peer-Reviewed Original ResearchConceptsCortisol synthesis inhibitorOpioid usePlacebo treatmentCocaine useDouble-blind trialMorning cortisol levelsStress-induced reinstatementCocaine-related behaviorsSynthesis inhibitorSubstance abuse problemsMethadone treatmentWithdrawal symptomsKetoconazole treatmentPharmacological adrenalectomyClinical trialsBlind trialSide effectsCocaine abuseCortisol levelsMethadoneNormal valuesPatientsSubjective effectsKetoconazoleTreatment implications
1999
Limited Efficacy of Ketoconazole in Treatment-Refractory Major Depression
Malison R, Anand A, Pelton G, Kirwin P, Carpenter L, McDougle C, Heninger G, Price L. Limited Efficacy of Ketoconazole in Treatment-Refractory Major Depression. Journal Of Clinical Psychopharmacology 1999, 19: 466-470. PMID: 10505589, DOI: 10.1097/00004714-199910000-00011.Peer-Reviewed Original ResearchConceptsTreatment-refractory major depressionClinical Global Impression ScaleBeck Depression InventoryMajor depressionLimited efficacyTreatment-refractory major depressive disorderPlacebo-controlled trialGlobal Impression ScaleEfficacy of ketoconazoleHamilton Rating ScaleMajor depressive disorderAssessment of moodCGI scoresImpression ScaleDepressive disorderPatientsDepression InventoryRating ScaleKetoconazolePlaceboDepressionEfficacySignificant reductionTrials
1997
Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects
Price L, Cappiello A, Malison R, McDougle C, Pelton G, Schöllnhammer G, Heninger G. Effects of Antiglucocorticoid Treatment on 5-HT1A Function in Depressed Patients and Healthy Subjects. Neuropsychopharmacology 1997, 17: 246-257. PMID: 9326749, DOI: 10.1016/s0893-133x(97)00049-3.Peer-Reviewed Original ResearchConceptsDepressed patientsReceptor functionHealthy control subjectsUnipolar depressed patientsAntiglucocorticoid treatmentAntidepressant actionGlucocorticoid modulationPreclinical findingsAdrenal axisControl subjectsAntidepressant activityClinical studiesTest doseHealthy subjectsReceptor sensitivityIpsapironeCortisol biosynthesisKetoconazoleDepressionPatientsBehavioral responsesSubjectsGlucocorticoidsAgonistsNeuroendocrine
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