N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6
Dela Cruz CS, Lee Y, Viswanathan SR, El-Guindy AS, Gerlach J, Nikiforow S, Shedd D, Gradoville L, Miller G. N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6. Journal Of Experimental Medicine 2004, 199: 503-514. PMID: 14970177, PMCID: PMC2211829, DOI: 10.1084/jem.20031205.Peer-Reviewed Original ResearchConceptsVIL-6Janus tyrosine kinaseSimilar biological functionsActivator of transcriptionGp130 receptor subunitCellular IL-6Distinct functional rolesFunctional homologueBiological functionsSignal transducerTyrosine kinaseFunctional roleKaposi's sarcoma herpesvirusCell proliferation bioassayGlycosylationCell proliferationReceptor subunitsGp130B cell proliferationN89PathwayOptimal functionTranscriptionHomologuesKinase
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