2009
Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation*
Dela Cruz CS, Viswanathan SR, El-Guindy AS, Shedd D, Miller G. Complex N-Linked Glycans on Asn-89 of Kaposi Sarcoma Herpes Virus-encoded Interleukin-6 Mediate Optimal Function by Affecting Cytokine Protein Conformation*. Journal Of Biological Chemistry 2009, 284: 29269-29282. PMID: 19690161, PMCID: PMC2785557, DOI: 10.1074/jbc.m109.039115.Peer-Reviewed Original ResearchConceptsVIL-6IL-6RalphaProtein conformationComplex glycansHuman cellular homologueSimilar biological functionsKaposi's sarcoma-associated herpesvirusAsn-89Conformation-specific antibodiesCellular homologueCytokine functionSarcoma-associated herpesvirusProtein functionHigh-mannose glycansBiological functionsViral cytokineDigestion assaysMannose glycansGp130Optimal functionGlycansGlycosylationHuman IL-6HuIL-6Intracellular production
2004
N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6
Dela Cruz CS, Lee Y, Viswanathan SR, El-Guindy AS, Gerlach J, Nikiforow S, Shedd D, Gradoville L, Miller G. N-linked Glycosylation Is Required for Optimal Function of Kaposi's Sarcoma Herpesvirus–encoded, but Not Cellular, Interleukin 6. Journal Of Experimental Medicine 2004, 199: 503-514. PMID: 14970177, PMCID: PMC2211829, DOI: 10.1084/jem.20031205.Peer-Reviewed Original ResearchConceptsVIL-6Janus tyrosine kinaseSimilar biological functionsActivator of transcriptionGp130 receptor subunitCellular IL-6Distinct functional rolesFunctional homologueBiological functionsSignal transducerTyrosine kinaseFunctional roleKaposi's sarcoma herpesvirusCell proliferation bioassayGlycosylationCell proliferationReceptor subunitsGp130B cell proliferationN89PathwayOptimal functionTranscriptionHomologuesKinase
1999
Cellular Tropism and Viral Interleukin-6 Expression Distinguish Human Herpesvirus 8 Involvement in Kaposi’s Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman’s Disease
Staskus K, Sun R, Miller G, Racz P, Jaslowski A, Metroka C, Brett-Smith H, Haase A. Cellular Tropism and Viral Interleukin-6 Expression Distinguish Human Herpesvirus 8 Involvement in Kaposi’s Sarcoma, Primary Effusion Lymphoma, and Multicentric Castleman’s Disease. Journal Of Virology 1999, 73: 4181-4187. PMID: 10196314, PMCID: PMC104197, DOI: 10.1128/jvi.73.5.4181-4187.1999.Peer-Reviewed Original ResearchConceptsViral gene expressionMulticentric Castleman's diseasePrimary effusion lymphomaLevel of expressionCell typesGene expressionViral genesKaposi's sarcomaInfected cell typesLytic cycle viral gene expressionHeterogeneous cell typesCastleman's diseaseInterleukin-6Lytic cycle genesEffusion lymphomaHuman immunodeficiency virus-positive individualsPathogenesis of PELPredominant infected cell typeHuman herpesvirus 8 infectionViral homologueVirus-positive individualsVIL-6B cell growthAltered expressionGenesKinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression
Sun R, Lin S, Staskus K, Gradoville L, Grogan E, Haase A, Miller G. Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression. Journal Of Virology 1999, 73: 2232-2242. PMID: 9971806, PMCID: PMC104468, DOI: 10.1128/jvi.73.3.2232-2242.1999.Peer-Reviewed Original ResearchConceptsHerpesvirus gene expressionKaposi's sarcoma-associated herpesvirusSarcoma-associated herpesvirusGene expressionLytic cycleEarly genesVIL-6Cell linesKSHV DNA replicationG protein-coupled receptorsProtein-coupled receptorsSingle-cell assaysPrimary effusion lymphoma cell linesImmediate early genesPAN RNADNA replicationEpstein-Barr virus BZLF1Nuclear RNALate genesBovine herpesvirus 4KS biopsiesPEL cell linesVBcl-2Positional homologueKinetic classes
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