Asymmetric synthesis of amines using tert-butanesulfinamide
Xu HC, Chowdhury S, Ellman JA. Asymmetric synthesis of amines using tert-butanesulfinamide. Nature Protocols 2013, 8: 2271-2280. PMID: 24157547, DOI: 10.1038/nprot.2013.134.Peer-Reviewed Original ResearchConceptsTert-butanesulfinamideAsymmetric synthesisClick chemistry applicationsReliable asymmetric synthesisDiversity-oriented synthesisChemistry applicationsCarbonyl compoundsNucleophile additionAmine reagentsPeptide isosteresChiral aminesDifferent amine structuresAmine structureClasses of aminesGroup cleavageBioactive moleculesAminesDrug candidatesSynthesisTertiary carbinaminesBiological purposesPharmaceutical agentsPreparationDifferent biological purposesIsosteresAn efficient chemical synthesis of carboxylate-isostere analogs of daptomycin
Yoganathan S, Yin N, He Y, Mesleh MF, Gu YG, Miller SJ. An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin. Organic & Biomolecular Chemistry 2013, 11: 4680-4685. PMID: 23752953, PMCID: PMC4033608, DOI: 10.1039/c3ob40924d.Peer-Reviewed Original ResearchConceptsSide-chain carboxylic acid groupsDirect synthetic procedureEfficient chemical synthesisCarboxylic acid groupsCarboxylic acid moietySynthetic procedureChemical synthesisBackbone cyclizationEsterification protocolAcid groupsAcid moietyCarboxylate isosteresBackbone amidesSynthesisAspartic acidGlutamic acidAcidMoietyAnaloguesCyclizationEfficient methodIsosteresAmidesHerein
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