2021
A Summary on Up-To-Date Research on Fungal Siderophores on Disease, Treatment and Pathogenicity Based on Text Mining, Bioinformatics and Experts’ Opinion
Prabahar A, Shanmugam L, Jose M, Radhakrishnan K, Raja K. A Summary on Up-To-Date Research on Fungal Siderophores on Disease, Treatment and Pathogenicity Based on Text Mining, Bioinformatics and Experts’ Opinion. Fungal Biology 2021, 187-210. DOI: 10.1007/978-3-030-53077-8_12.Peer-Reviewed Original ResearchSiderophore biosynthetic pathwaysFungal siderophoresBiosynthetic pathwayFungal diseasesTreatment of life-threatening infectionsIron acquisitionBioinformatics approachManual curationInfluence of siderophoresSiderophoreComprehensive collection of informationLife-threatening infectionsProtein targetsBacterial siderophoresFungiBioinformaticsTherapeutic targetComprehensive collectionPathwayAspergillosisFungalGenesPathogensCandidiasisProtein
2019
The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia
Muriuki J, Mentzer A, Band G, Gilchrist J, Carstensen T, Lule S, Goheen M, Joof F, Kimita W, Mogire R, Cutland C, Diarra A, Rautanen A, Pomilla C, Gurdasani D, Rockett K, Mturi N, Ndungu F, Scott J, Sirima S, Morovat A, Prentice A, Madhi S, Webb E, Elliott A, Bejon P, Sandhu M, Hill A, Kwiatkowski D, Williams T, Cerami C, Atkinson S. The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia. Science Advances 2019, 5: eaaw0109. PMID: 31517041, PMCID: PMC6726445, DOI: 10.1126/sciadv.aaw0109.Peer-Reviewed Original ResearchConceptsQ248H mutationMalaria-infected miceAssociated with modest protectionErythrocytes ex vivoFerroportin Q248H mutationAssociated with protectionStudies of limited sizeEvidence of protectionSevere malariaMalaria exposureMalaria parasitesQ248HHemolytic anemiaModest protectionIron deficiencyMalariaHuman studiesAfrican childrenAnemiaBacteremiaFerroportinMature erythrocytesMutationsIncreased fatalityIron acquisition
2018
Genome-Wide Characterization of the Fur Regulatory Network Reveals a Link between Catechol Degradation and Bacillibactin Metabolism in Bacillus subtilis
Pi H, Helmann J. Genome-Wide Characterization of the Fur Regulatory Network Reveals a Link between Catechol Degradation and Bacillibactin Metabolism in Bacillus subtilis. MBio 2018, 9: 10.1128/mbio.01451-18. PMID: 30377275, PMCID: PMC6212828, DOI: 10.1128/mbio.01451-18.Peer-Reviewed Original ResearchConceptsRegulatory networksCatechol degradationPutative DNA binding sitesGenome-wide identificationGenome-wide characterizationFerric uptake regulatorIron-dependent transcriptional repressorCellular iron requirementsDNA binding sitesIron-sufficient conditionsIron-limiting conditionsHigh-affinity iron chelatorsEnvironmental aromatic compoundsSiderophore bacillibactinFur regulonGenomic viewApo-FurRepressor functionTranscriptional repressorRegulated genesChromatin immunoprecipitationPositive regulatorIron acquisitionNegative regulationGenetic analysis
2008
RstA-Promoted Expression of the Ferrous Iron Transporter FeoB under Iron-Replete Conditions Enhances Fur Activity in Salmonella enterica
Jeon J, Kim H, Yun J, Ryu S, Groisman EA, Shin D. RstA-Promoted Expression of the Ferrous Iron Transporter FeoB under Iron-Replete Conditions Enhances Fur Activity in Salmonella enterica. Journal Of Bacteriology 2008, 190: 7326-7334. PMID: 18790861, PMCID: PMC2576650, DOI: 10.1128/jb.00903-08.Peer-Reviewed Original ResearchMeSH KeywordsBacterial ProteinsBlotting, WesternElectrophoretic Mobility Shift AssayGene ExpressionGene Expression ProfilingGene Expression Regulation, BacterialIronIron DeficienciesOligonucleotide Array Sequence AnalysisOperonPromoter Regions, GeneticProtein BindingRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionSalmonella entericaTranscription, GeneticConceptsFerrous iron transporter FeoBFur proteinIron-replete conditionsFur activityTarget genesIron-responsive genesWild-type levelsFerrous iron uptakeFeoAB operonFur geneTranscriptional activationIron acquisitionExpression experimentsRegulatory pathwaysTranscription levelsIron uptakeGenesPrimary regulatorRstAProteinFeOBRepressionSalmonella entericaPromoterExpression
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