2018
Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy
Guo X, Deng G, Liu J, Zou P, Du F, Liu F, Chen AT, Hu R, Li M, Zhang S, Tang Z, Han L, Liu J, Sheth KN, Chen Q, Gou X, Zhou J. Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy. ACS Nano 2018, 12: 8723-8732. PMID: 30107729, DOI: 10.1021/acsnano.8b04787.Peer-Reviewed Original ResearchConceptsBrain-targeted nanoparticlesIschemic brainEfficacy of glyburideImproved treatmentIschemic brain tissueEffective pharmacological approachBlood-brain barrierMatrix metalloproteinase-9Ischemic strokeStroke patientsStroke therapyMetalloproteinase-9Current treatmentPharmacological approachesBrain tissueIschemic microenvironmentTherapeutic drugsGreater delivery efficiencyBrainClinical applicationStrokeTreatmentTargeted deliveryEfficacyVariety of formulations
2006
First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy.
Schaefer P, Roccatagliata L, Ledezma C, Hoh B, Schwamm L, Koroshetz W, Gonzalez R, Lev M. First-pass quantitative CT perfusion identifies thresholds for salvageable penumbra in acute stroke patients treated with intra-arterial therapy. American Journal Of Neuroradiology 2006, 27: 20-5. PMID: 16418350, PMCID: PMC7976067.Peer-Reviewed Original ResearchConceptsCerebral blood volumeAcute stroke patientsCT perfusionStroke patientsCBF ratioGray matterWhite matterAbsolute cerebral blood volumeCBV ratioIntra-arterial therapyIschemic brain tissueQuantitative CT perfusionDynamic CT perfusionIA therapyRecanalization therapyStroke onsetSalvageable penumbraInfarct coreIschemic tissueUninvolved regionsIschemic regionBlood volumeCBF valuesPatientsBrain tissue
1999
Mice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury
Soriano S, Coxon A, Wang Y, Frosch M, Lipton S, Hickey P, Mayadas T. Mice Deficient in Mac-1 (CD11b/CD18) Are Less Susceptible to Cerebral Ischemia/Reperfusion Injury. Stroke 1999, 30: 134-139. PMID: 9880401, DOI: 10.1161/01.str.30.1.134.Peer-Reviewed Original ResearchConceptsTransient focal cerebral ischemiaRegional cerebral blood flowMac-1-deficient miceFocal cerebral ischemiaCerebral blood flowMac-1Cerebral ischemiaBrain sectionsBlood flowCerebral ischemia/reperfusion injuryFocal ischemia/reperfusionIschemia/reperfusion injuryLeft middle cerebral arteryCerebral cell deathLeukocyte beta2 integrinsIschemic brain tissueReperfusion-induced injuryMiddle cerebral arteryIschemia/reperfusionWild-type miceLaser Doppler flowmeterWild-type cohortsMac-1 deficiencyMacrophage-1 antigenInfarct volume
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply