Supervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction
Wang M, Patsenker J, Li H, Kluger Y, Kleinstein S. Supervised fine-tuning of pre-trained antibody language models improves antigen specificity prediction. PLOS Computational Biology 2025, 21: e1012153. PMID: 40163503, PMCID: PMC12013870, DOI: 10.1371/journal.pcbi.1012153.Peer-Reviewed Original ResearchConceptsSupervised fine-tuningImmune responseMolecular basis of antigen recognitionSARS-CoV-2 spike proteinLanguage modelSARS-CoV-2 vaccinesAdaptive immune responsesSpecific predictionsMolecular basisSpike proteinAntibody-based therapeuticsFine-tuningAntibody-antigen specificitySpecific to antigensInfluenza hemagglutininVaccine designAntigen recognitionModel embeddingsImmune functionLanguage model embeddingsSARS-CoV-2AntibodiesAntigenInfluenzaVaccine
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